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In Vitro Maturation IVF

This technique includes retrieval of immature eggs and growing them to full maturity in the laboratory


During in vitro maturation IVF, the woman either is not administered hormone medicine needed for ovulation stimulation or is administered a minimal dose. Consequently, the patient is not taking risks of ovarian hyperstimulation syndrome development at all. These are the factors that our specialists rely on when recommending IVM technique for infertility treatment. If the woman consents to the procedure it is implemented with: 

contraindications to the full-value hormone stimulation;
polycystic ovarian syndrome;
high risks of OHSS (Ovarian Hyperstimulation Syndrome) or OHSS in anamnesis;
an inadequate response to artificial stimulation.

What is IVM (In Vitro Maturation) IVF?

This technique employs retrieval of immature eggs and a procedure of growing them to full maturity in the laboratory. In vitro maturation, IVF aims to generate some oocytes ready to be fertilized. This technique works as well in cases of inadequate follicular maturation and contraindications for or ineffectiveness of aggressive impact on hormone level. It is the main advantage of this revolutionary technique.

Why Life Line is your best choice for In Vitro Maturation IVF?

Today in vitro maturation IVF is adopted in most developed countries. It is not the most efficient ART technique, but it might be the last chance for some couples to conceive a child without a donor egg. Over 1000 of healthy babies were brought to life thanks to this new infertility treatment procedure. However, only a few clinics in Moscow have already introduced in vitro maturation IVF, and Life Line care center is one of them. This technique is fully mastered by our reproductologists and embryologist, all the IVM programs are implemented according to European standards and at the European level. In terms of performance indicators, our center is highly competitive with the world’s leading clinics.  

How In Vitro Maturation IVF process goes in Life Line care center

In vitro fertilization does not require any preparatory phase apart from the standard pre-IVF examination. During artificial fertilization procedure hormone stimulation is not employed at all or employed at a minimum and only to set the egg maturation process.

The first phase of the program in the Life Line Reproductive care center includes estimating the patient’s ovulation time and referring the patient for two ultrasound scans. The first folliculometry ultrasound is undertaken on the 2nd or 3rd day of the woman’s menstrual cycle. For the second scan, the patient comes to the center on the 6th - 9th day. During the ultrasound procedure, a doctor determines the number of rapidly-developing follicles and estimates endometrium state.

Oocytes are retrieved on the 8th - 12th day of the menstrual cycle. Follicular puncture is typically performed transvaginally. It is a meticulous procedure as the size of a follicle at this stage is 2-3 times smaller than of those in full maturity. It requires clinical excellence and lots of experience of the reproductologist and assisting medical staff. That is why in vitro maturation IVF can be implemented only in advanced reproductive care centers. The procedure lasts for 30-40 minutes, it is conducted under anesthesia and monitored via ultrasound.

In the next phase, embryologists are involved. They place immature oocytes into special culture medium containing hormones. Once placed, oocytes are grown to the metaphase stage II or, in other words, to the state of egg receptiveness. This process takes 24-48 hours. ICSI technology is employed for fertilization of mature cells. The embryo is transferred to the uterus as soon as on the 3rd - 5th day after oocytes fertilization. Sometimes the transfer is recommended to be delayed until the next menstrual cycle. In this case, the embryo is vitrificated (сryonic preservation procedure).

To sum up

  • Oocyte retrieval is implemented during the natural menstrual cycle, so there is no need either in ovulation stimulation procedure or in hormone concentration raise. 
  • It results in the generation of several eggs, unlike in the natural cycle IVF with only one egg at the end. It increases the chances for a successful conception in above-mentioned cases and guarantees no need in repeating punctures in case of a failure. 
  • This technique is the closest to the natural egg maturation process of that in a female body and eliminates risks of ovarian hyperstimulation syndrome development. 
  • In vitro maturation IVF procedure is the last chance for some couples to conceive a child without a donor egg. 

Today efficiency level of in vitro maturation IVF is much lower than that of standard programs that include multi follicular ovarian stimulation induction. But it is higher than the one of the natural cycle IVF for a certain number of patients. The technique of the procedure implementation is being developed constantly and its results are getting better. This is partly owing to the exploratory activity of the reproductologists of Life Line care center. 

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