The program in detail
During donor eggs IVF, donor gamete cells are fertilized with the partner's sperm, the received embryos are cultured and then transferred to the uterus of the mother-to-be. The next stages are pregnancy and delivery. IVF with donor eggs guarantees high chances for the successful outcome. Our center shows particularly impressive results: the chances for the positive outcome of in vitro fertilization with donor oocytes go up to 70%.
Where in Moscow can you undergo IVF with donor oocytes? Welcome to Life Line care center!
In our clinic, IVF with donor eggs is implemented in accordance with international standards. We have two donor oocytes programs to offer to our patients:
- with donor stimulation for the mother-to-be;
- with vitrified donor oocytes.
Experienced reproductologists and embryologists are in charge of those programs. Specialists employ technologically advanced modern equipment and the latest materials. Our center has its own cryobank that offers a wide choice of donor gamete cells of high quality that are thoroughly examined.
Indications for Donor Eggs IVF
There are circumstances in which conception and delivery cannot happen without the genetic material of another woman. IVF with donor oocytes is recommended in case of:
- primary ovarian insufficiency;
- ovarian structure impairment;
- genetic disorders transferred via female lineage (if the patient does not want to go through PGD);
- unsuccessful IVF attempts in the past due to ovarian insufficiency;
- infertility caused by radiation or chemicals.
Donor Eggs IVF program schedule
In vitro fertilization is the procedure of conception conducted outside the female body in the laboratory. The conventional protocol starts with ovarian stimulation, i.e. administration of hormone medicine to generate more than one egg within one cycle. After that, a doctor retrieves oocytes of the mother-to-be via a puncture procedure and transfers them to the laboratory where they can be inseminated by sperm of the father-to-be. Received embryos are then grown to their full maturity and one or two best ones are transferred to the patient's uterine cavity for the pregnancy to happen.
Programs with donor eggs distinguish themselves from natural IVF cycle by employing donor oocytes to culture embryos. The scheme they follow is the same, except for the phases of stimulation and follicular puncture procedures (both of them are undertaken with a donor, not with a recipient). The program details differ from one another according to the donor biomaterial IVF type chosen.
Donor Eggs IVF: steps of the program
Donor Eggs IVF types available in Life Line care center
Our patients can choose donor biomaterial by themselves. Parents-to-be have two options. They can either involve their relatives/friends to participate in the program or employ oocytes received from one of the anonymous donors listed in Life Line catalog. The option with involving relatives is much preferable as IVF procedure would be conducted with a biomaterial that is genetically close to the recipient. Unfortunately, not all couples have such an opportunity. It is a more common practice to perform an IVF procedure with biomaterial given by anonymous donors. Couples have a choice here as well between the employment of either fresh or vitrified donor eggs.
1. Fresh donor oocyte program
Parents-to-be can choose among donors listed in Life Line catalog. The next stage is multifollicular ovarian stimulation in the donor. Simultaneously specialists undertake the process of synchronizing menstrual cycles in both women. The objective is to avoid transfer delays and prepare the patient's endometrium for the embryo implantation. After that, a follicular puncture in the donor is performed. Received eggs are fertilized with the partner's sperm. After several days of culture in an incubator, embryos are transferred to the uterus of the mother-to-be. 2 weeks later HCG blood test is conducted. For the IVF with a relative donor the scheme is the same.
2. Comprehensive program with vitrified donor eggs.
This IVF option is implemented with vitrified anonymous donors’ cells received from our cryobank. Vitrification is a type of freezing that is optimal for the insurance of oocytes’ continued viability. It is the only method we practice in our clinic. After being thawed like this, the eggs are as good as the fresh ones. In this case, the synchronization of donor’s and patient’s menstrual cycles is excluded.
But there is one aspect not to be ignored. About 20% of oocytes can deteriorate in the process of thawing however strong the performance of the vitrification procedure was. In programs with added assurance, Life Line care center assumes these problems while the patients are guaranteed to have a chosen number of oocytes. In case of eggs loss during the thawing process, a corresponding number of eggs will be additionally thawed, otherwise, you will get a refund.
Embryo PGD as the procedure for the most responsible parents-to-be
The donor program is often supported with such an additional phase as preimplantation genetic diagnosis (PGD). This screening aims to detect chromosomal and genetic abnormalities and allows for the selection and transfer of exceptionally healthy embryos. How the procedure is performed? 5-day embryos received from donor eggs undergo the biopsy for PGD. Tissues are sent for further analysis whereas embryos undergo the procedure of freezing and remain in this state pending the results. The transfer is undertaken under cryoprotocole. PGD is available either with vitrified or fresh donor oocytes. If the procedure supports fresh cell program, synchronizing of menstrual cycles in donor and patient is unnecessary — there is no need for synchronization under the cryoprotocole.
Donor egg IVF pricing
The price for the donor egg IVF procedure depends on the type chosen. For obvious reasons the program with a relative as a donor is cheaper — here the patients do not need to pay for the donor biomaterial. The price for the comprehensive program with vitrified donor eggs is lower than for the IVF with donor stimulation for the mother-to-be. Your attending reproductologist will help to understand which option is optimum in your particular case.
How egg donors are selected?
In our cryobank, we only store high-quality biomaterial with a high potential for fertilization and healthy baby delivery. Oocyte donors are thoroughly examined and prepared. That is the reason for the maximum in vitro fertilization performance at first try.
All of the egg donors meet the following criteria:
- the age between 21 and 33,
- has already given birth to a healthy child
- good physical and mental health,
- absence of congenital defects,
- weight within the normal range,
- pleasant visage, no distinct phenotypic traits.
By law, donors have to undergo a series of tests enshrined in the Order by the Ministry of Health that deals with the reproductive technologies sphere:
- a physical examination performed by a therapist;
- a physical examination performed by a gynecologist, including ovarian reserve evaluation;
- psychiatrist counseling;
- ECG and fluorography;
- blood and urine tests, including those for HIV, RW, hepatitis;
- gynecologic smears;
- karyotype examination;
In our clinic, we do not limit ourselves to this list. In addition, our donors undergo genotype testing to define if there are any of 46 harmful mutations. Genetic screening allows eliminating the risk of 23 diseases (mucoviscidosis, Gierke and Tay-Sachs diseases, polycystic kidney disease, etc.).
Once a candidate is approved, the following donor characteristics enter the Life Line catalog: phenotype (eye and hair color, other appearance details), height, body-build, profession, psychological characteristics, a childhood photo). This and all the other information is used by parents-to-be when choosing a donor. Couples tend to choose the donor that most resembles the mother-to-be so that the future child would bear similarity to both parents.
Come to us to meet your long-awaited baby!
Life Line Reproductive care center is one of the most advanced in Moscow. Reproductologists and embryologists of our center are all highly-qualified and possess immense practical experience. Our specialists constantly improve their skills, follow new technology tendencies, participate in thematic forums, conferences and seminars. The patients of donor programs are under the care of specialists that focus on this field.
To improve chances for pregnancy in our laboratories we employ high-precision microscopes and most-advanced culture media. All the above-mentioned and thorough donor selection maximize chances for pregnancy at first try!
To make an appointment with reproductologist call the numbers listed or submit an application form below.